{"created":"2023-05-15T11:33:54.960903+00:00","id":180,"links":{},"metadata":{"_buckets":{"deposit":"f14dcebe-9dfa-4cec-8ec4-55e80a1e23ac"},"_deposit":{"created_by":2,"id":"180","owners":[2],"pid":{"revision_id":0,"type":"depid","value":"180"},"status":"published"},"_oai":{"id":"oai:cur-ren.repo.nii.ac.jp:00000180","sets":["2:6:14"]},"author_link":["7543","7545","7542","7544"],"item_10002_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"19","bibliographicPageStart":"13","bibliographicVolumeNumber":"12","bibliographic_titles":[{"bibliographic_title":"Chugokugakuen journal"}]}]},"item_10002_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Intracellular pH homeostasis is the essential element for living cells. Optimal pH has to be provided for proteins to function properly within the cells. pH is kept at around 7.3 in most cells from bacterial to mammalian. In contrast, for various endosomes in the cytoplasm their own weak acidic pH is maintained. For the homeostatic pH regulation in the compartments like cytoplasm and endosomal lumen are performed by H+\ntransporting membrane integral proteins. One of these is the Na+\n/H+\nexchanger (NHE or Nha). Here the roles of Na+\n/H+\nexchangers in the cells are summarized based on our recent findings. One of the most important findings is that the acidic pH regulated by NHE in the yeast endosomes contributes to recruitment of various factors required for membrane protein trafficking on the membrane surface of the endosomes. This acidic pH leads to multivesicular body (MVB) formation. These observations raise a new important role for NHE, not only in the pH regulation of the endosome lumen but also for pH regulation on the cytoplasmic surface of the endosomes. Based on this new physiological role of organellar NHE from yeast (Nhx1) we propose a new conceptual idea of the importance of local protons regulated by the NHEs in cell physiology.","subitem_description_type":"Abstract"}]},"item_10002_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"中国学園大学/中国短期大学"}]},"item_10002_relation_16":{"attribute_name":"情報源","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"1. Futai, M., Oka, T., Sun-Wada, G., Moriyama, Y., Kanazawa, H., and Wada, Y. (2000) J. Exp. Biol. 203, 107-116.\n"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"2. Casey, J. R., Grinstein, S. and Orlowski, J. (2010) Nat. Rev. Mol. Cell, Biol. 11, 50-61.\n"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"3. Padan, E., Venturi, M., Gerschman, Y., Dover, N. (2001) Biochim Biophys Acta 1185, 129-151.\n"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"4. Futai, M. and Kanazawa, H. (1983) Microbiol. Rev. 47, 285-312.\n"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"5. Counillon, L., and Poyssegur, J. (2000) J. Biol. Chem., 275, 22373-22376.\n"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"6. Sardet, C., Franchi, A. and Pouyssegur, J (1989) Cell, 56, 271-280.\n"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"7. Ohgaki, R., van Ijzendoorn, S. V., Matsushita, M., Hoekstra, D., and Kanazawa, H. (2011) Biochemistry, 50, 443-450.\n"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"8. Nakamura, N., Tanaka, S., Teko, Y., Mitsui, K., and Kanazawa, H. (2005) J. Biol. Chem., 280, 1561-1572.\n"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"9. Brett, C. L., Wei, Y., Donowitz, M., and Rao, R. (2002) Am. J. Phys. Cell Phys. 282, 1031-1041.\n"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"10. Fukura, N., Ohgaki, R., Matsushita, M., Nakamura, N., Mitsui, K., and Kanazawa, H. (2010) J. Membrane Biol. 234, 149-158.\n"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"11. Ohgaki, R., Fukura, N., Matsushita, M., Mitsui, K., and Kanazawa, H. (2008) J. Biol. Chem. 283, 4417-4429.\n"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"12. Lou, X., Matsushita, M., Numaza, M., Taguchi, A., Mitsui, K., and Kanazawa, H. (2011) Am. J. Phys. Cell Phys., 301, 1431-1444.\n"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"13. Ohgaki, R., Matsushita, M., Kanazawa, H., Ogihara, S., Hoekstra, D., and van IJzendoorn, S. V. (2010) Mol. Biol. Cell 21, 1293-1304.\n"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"14. Garben, J. Y., Neuman, M., Trojanowski, J., Q., Lee, V. M., Feldman, G., Norris, J. W., Friez, M. J., Schwartz, C. E., Stevenson, R., and Sima, A. A. (2010) Brain, 1391-1420.\n"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"15. Takahashi, Y., Hosoki, K., Matsushita, M., Funatsuka, M., Saito, K., Kanazawa, H., Goto, Y., and Saito, S. (2011) Am. J. Med. Genetics, 799-807.\n"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"16. Matsushita, M. Suzuki, S., Nishihara, Y., and Kanazawa, H. personal communi. (2012)\n"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"17. Devlin, B., and Sherer, S. W. (2012) Current Opinion in Genetics and development 22, 229-237.\n"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"18. Nass, R. and Rao, R. (1998) J. Biol. Chem. 273, 21054-21060.\n"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"19. Raymond, C, K., Howald-Stevenson, I., Vater, C. A. and Stevens, T. H. (1992) Mol. Biol. Cell 3, 1389-1402.\n"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"20. Mitsui, K., Koshimura, Y., Yoshikawa, Y., Matsushita, M., and Kanazawa, H. (2011) J. Biol. Chem. 286, 37625-37638.\n"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"21. Raiborg, C., and Stenmark, H. (2009) Nature, 458, 445-452.\n"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"22. Kally L. M., Brett, C. L., Tukaye, D. N., Wemmer, M., Chyou, A., Odorizzi, G., and Rao, R. (2011) J. Biol. Chem., 286, 44067-44077.\n"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"23. Katzman, D., Stefan, C. J., Babst, M., and Emr, S. D. (2001) J. Cell. Biol. 162, 413-423.\n"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"24. Mitsui, K., Izumida, K., Matsushita, M. and Kanazawa, H. Personal Communi.\n"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"25. Diering GH, Mills F, Bamji SX, Numata M. (2011) Mol Biol Cell. 2011 22, 2246-57.\n"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"26. Hisamitsu, T., Nakamura, T. Y., and Wakabasyashi, S. (2012) Mol. Cell. Biol. 32, 3265-3280."}]}]},"item_10002_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"中国学園大学/中国短期大学"}]},"item_10002_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11806612","subitem_source_identifier_type":"NCID"}]},"item_10002_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1348-1452","subitem_source_identifier_type":"ISSN"}]},"item_10002_subject_21":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"460","subitem_subject_scheme":"NDC"}]},"item_10002_text_24":{"attribute_name":"出版者（英）","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Chugokugakuen University / Chugoku Junior Cllege"}]},"item_10002_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kanazawa, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mitsui, Keiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kanazawa, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mitsui, Keiji","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-10-04"}],"displaytype":"detail","filename":"12_013_020.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"12_013_020.pdf","url":"https://cur-ren.repo.nii.ac.jp/record/180/files/12_013_020.pdf"},"version_id":"e32cdc7c-534b-488d-9bee-c9256793e773"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"pH regution","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Na＋/H＋exchangers","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ion transporter","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"multivesicular body","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"membrane trafficking","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pH regution","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Na＋/H＋exchangers","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ion transporter","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"multivesicular body","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"membrane trafficking","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A Novel Implication of the Physiological Importance of Local Protons at the Membrane Surface of Organellar Vesicles in Eukaryote Cells: Organellar Type Na+ from Saccharomyces cerevisiae Plays an Important Role in the Formation of Multivesicular Bodies","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A Novel Implication of the Physiological Importance of Local Protons at the Membrane Surface of Organellar Vesicles in Eukaryote Cells: Organellar Type Na+ from Saccharomyces cerevisiae Plays an Important Role in the Formation of Multivesicular Bodies","subitem_title_language":"en"}]},"item_type_id":"10002","owner":"2","path":["14"],"pubdate":{"attribute_name":"公開日","attribute_value":"2018-10-04"},"publish_date":"2018-10-04","publish_status":"0","recid":"180","relation_version_is_last":true,"title":["A Novel Implication of the Physiological Importance of Local Protons at the Membrane Surface of Organellar Vesicles in Eukaryote Cells: Organellar Type Na+ from Saccharomyces cerevisiae Plays an Important Role in the Formation of Multivesicular Bodies"],"weko_creator_id":"2","weko_shared_id":-1},"updated":"2023-05-15T11:52:41.741102+00:00"}