@article{oai:cur-ren.repo.nii.ac.jp:00000167, author = {Seki, Shuji and Sarke, Altaf H. and Nakamura, Takashi and Seki, Yuichi and Ikeda, Shogo and Seki, Shuji and Sarke, Altaf H. and Nakamura, Takashi and Seki, Yuichi and Ikeda, Shogo}, journal = {Chugokugakuen journal}, month = {}, note = {Genomic cloning and sequencing of a chicken homolog (chNthll) for Escherichia coli endonuclease Ⅲ, that is involved in pyrimidine base excision repair, were performed. The sequence covered the entire chNthll gene consisting of six exons and five introns spanning 4.9kb with 5' flanking (6.6kb) and 3' flanking (3.lkb) regions. The boundaries between exon and intron follow the GT/AG rule. The sequenced 5' flanking region lacks typical TATA and CAAT boxes, but contains a CpG island having putative binding sites for several transcription factors such as Ests 1 and Spl. The chNthll gene lies immediately adjacent to the tuberous sclerosis 2 (chTsc2) gene in a 5'-to-5' orientation. Downstream of the chNthll gene, the gene for the regulatory factor 2 (chSlc9a3r2) of the solute carrier family 9 (sodium/hydrogen exchanger), isoform A3, lies in a 3'-to-3' orientation. The genomic organization of the chNthll gene and the relative orientation of the gene with the adjacent genes of chTsc2 and chSlc9a3r2 are similar to those in human and mouse genomes.}, pages = {23--27}, title = {Genomic structure and sequence of a chicken homolog\n(chNthl1) of Escherichia coli endonuclease III with those of\nthe adjacent parts of chTsc2 and chSlc9a3r2 genes}, volume = {6}, year = {2007} }